Reaction Details | |||
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Target | Signal transducer and activator of transcription 3 | ||
Ligand | BDBM50252660 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_487803 (CHEMBL1019235) | ||
EC50 | 130±n/a nM | ||
Citation | Xu, J; Cole, DC; Chang, CP; Ayyad, R; Asselin, M; Hao, W; Gibbons, J; Jelinsky, SA; Saraf, KA; Park, K Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem51:4115-21 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Signal transducer and activator of transcription 3 | |||
Name: | Signal transducer and activator of transcription 3 | ||
Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | ||
Type: | Protein | ||
Mol. Mass.: | 88064.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P40763 | ||
Residue: | 770 | ||
Sequence: |
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BDBM50252660 | |||
n/a | |||
Name | BDBM50252660 | ||
Synonyms: | Benzyl 1-(4-Cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | CHEMBL493450 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H9F7N2O3 | ||
Mol. Mass. | 506.3287 | ||
SMILES | Fc1cc2c(c(F)c1F)n(cc(C(=O)OCc1ccccc1)c2=O)-c1c(F)c(F)c(C#N)c(F)c1F |(-10.27,-12.39,;-8.94,-13.16,;-7.61,-12.39,;-6.28,-13.15,;-6.27,-14.71,;-7.61,-15.48,;-7.61,-17.02,;-8.94,-14.7,;-10.28,-15.47,;-4.93,-15.48,;-3.58,-14.7,;-3.59,-13.14,;-2.26,-12.37,;-2.26,-10.83,;-.92,-13.13,;.41,-12.36,;1.75,-13.13,;1.74,-14.66,;3.08,-15.43,;4.41,-14.65,;4.4,-13.11,;3.06,-12.35,;-4.94,-12.37,;-4.95,-10.83,;-4.92,-17.01,;-3.59,-17.77,;-2.26,-16.99,;-3.58,-19.31,;-2.24,-20.07,;-4.91,-20.09,;-4.91,-21.63,;-4.92,-23.16,;-6.25,-19.32,;-7.58,-20.09,;-6.25,-17.78,;-7.6,-18.54,)| | ||
Structure |