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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Signal transducer and activator of transcription 3 | ||
| Ligand | BDBM50252612 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_487803 (CHEMBL1019235) | ||
| EC50 | 170±n/a nM | ||
| Citation |  Xu, J; Cole, DC; Chang, CP; Ayyad, R; Asselin, M; Hao, W; Gibbons, J; Jelinsky, SA; Saraf, KA; Park, K Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem51:4115-21 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Signal transducer and activator of transcription 3 | |||
| Name: | Signal transducer and activator of transcription 3 | ||
| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | ||
| Type: | Protein | ||
| Mol. Mass.: | 88064.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P40763 | ||
| Residue: | 770 | ||
| Sequence: |
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| BDBM50252612 | |||
| n/a | |||
| Name | BDBM50252612 | ||
| Synonyms: | CHEMBL524195 | Ethyl 1-(4-Cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquino-line-3-carboxylate | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H7F7N2O3 | ||
| Mol. Mass. | 444.2593 | ||
| SMILES | CCOC(=O)c1cn(-c2c(F)c(F)c(C#N)c(F)c2F)c2c(F)c(F)c(F)cc2c1=O |(32.1,3.51,;30.76,4.28,;29.43,3.5,;28.1,4.27,;28.09,5.81,;26.77,3.49,;26.77,1.94,;25.43,1.16,;25.44,-.37,;26.77,-1.13,;28.1,-.36,;26.78,-2.67,;28.11,-3.43,;25.44,-3.45,;25.45,-4.99,;25.44,-6.52,;24.1,-2.68,;22.77,-3.46,;24.1,-1.15,;22.76,-1.91,;24.09,1.93,;22.75,1.16,;22.74,-.38,;21.41,1.93,;20.08,1.16,;21.41,3.48,;20.08,4.25,;22.74,4.25,;24.08,3.48,;25.41,4.27,;25.41,5.81,)| | ||
| Structure | 
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