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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Signal transducer and activator of transcription 3 | ||
| Ligand | BDBM50252611 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_487803 (CHEMBL1019235) | ||
| EC50 | 46000±n/a nM | ||
| Citation |  Xu, J; Cole, DC; Chang, CP; Ayyad, R; Asselin, M; Hao, W; Gibbons, J; Jelinsky, SA; Saraf, KA; Park, K Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem51:4115-21 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Signal transducer and activator of transcription 3 | |||
| Name: | Signal transducer and activator of transcription 3 | ||
| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | ||
| Type: | Protein | ||
| Mol. Mass.: | 88064.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P40763 | ||
| Residue: | 770 | ||
| Sequence: |
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| BDBM50252611 | |||
| n/a | |||
| Name | BDBM50252611 | ||
| Synonyms: | 5,6,7,8-Tetrafluoro-4-oxo-1-(pentafluoro-phenyl)-1,4-dihydroquinoline-3-carboxylic acid | CHEMBL494258 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H2F9NO3 | ||
| Mol. Mass. | 427.1776 | ||
| SMILES | OC(=O)c1cn(-c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2c1=O |(15.58,3.17,;14.25,3.94,;14.24,5.48,;12.92,3.17,;12.92,1.61,;11.58,.83,;11.59,-.7,;12.92,-1.46,;14.24,-.68,;12.93,-2.99,;14.26,-3.76,;11.59,-3.78,;11.6,-5.31,;10.26,-3.01,;8.92,-3.78,;10.25,-1.47,;8.91,-2.23,;10.24,1.6,;8.9,.83,;8.9,-.7,;7.57,1.6,;6.23,.84,;7.57,3.15,;6.23,3.92,;8.9,3.92,;8.89,5.46,;10.23,3.15,;11.57,3.94,;11.56,5.48,)| | ||
| Structure | 
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