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TargetHistamine receptor H3
LigandBDBM50262939
Substrate/Competitorn/a
Meas. Tech.ChEMBL_489016
Ki 4.3±n/a nM
Citation Nagase TMizutani TIshikawa SSekino ESasaki TFujimura TIto SMitobe YMiyamoto YYoshimoto RTanaka TIshihara ATakenaga NTokita SFukami TSato N Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem 51:4780-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine receptor H3
Name:Histamine receptor H3
Synonyms:n/a
Type:Enzyme
Mol. Mass.:48611.84
Organism:Macaca mulatta (Rhesus macaque)
Description:Q865E1
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50262939
n/a
NameBDBM50262939
Synonyms:2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone | CHEMBL476323
TypeSmall organic molecule
Emp. Form.C23H24F3N3O2
Mol. Mass.431.4508
SMILESCc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F
Structure
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