| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine receptor H3 |
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| Ligand | BDBM50262939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_489016 (CHEMBL986357) |
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| Ki | 4.3±n/a nM |
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| Citation |  Nagase, T; Mizutani, T; Ishikawa, S; Sekino, E; Sasaki, T; Fujimura, T; Ito, S; Mitobe, Y; Miyamoto, Y; Yoshimoto, R; Tanaka, T; Ishihara, A; Takenaga, N; Tokita, S; Fukami, T; Sato, N Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem51:4780-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine receptor H3 |
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| Name: | Histamine receptor H3 |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 48611.84 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | Q865E1 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
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| BDBM50262939 |
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| n/a |
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| Name | BDBM50262939 |
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| Synonyms: | 2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone | CHEMBL476323 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24F3N3O2 |
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| Mol. Mass. | 431.4508 |
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| SMILES | Cc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F |
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| Structure | 
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