| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
|---|
| Ligand | BDBM50262972 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_490135 (CHEMBL994440) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Zhu, C; Hansen, AR; Bateman, T; Chen, Z; Holt, TG; Hubert, JA; Karanam, BV; Lee, SJ; Pan, J; Qian, S; Reddy, VB; Reitman, ML; Strack, AM; Tong, V; Weingarth, DT; Wolff, MS; MacNeil, DJ; Weber, AE; Duffy, JL; Edmondson, SD Discovery of imidazole carboxamides as potent and selective CCK1R agonists. Bioorg Med Chem Lett18:4393-6 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholecystokinin receptor type A |
|---|
| Name: | Cholecystokinin receptor type A |
|---|
| Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 47859.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Stable expression of human CCK-1 receptors in HEK 293 cells. |
|---|
| Residue: | 428 |
|---|
| Sequence: | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
|
|
|
|---|
| BDBM50262972 |
|---|
| n/a |
|---|
| Name | BDBM50262972 |
|---|
| Synonyms: | (4-(naphthalen-2-yl)piperazin-1-yl)(2-p-tolyl-1-(3-(2,2,2-trifluoroethoxy)phenyl)-1H-imidazol-4-yl)methanone | CHEMBL448597 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H29F3N4O2 |
|---|
| Mol. Mass. | 570.6042 |
|---|
| SMILES | Cc1ccc(cc1)-c1nc(cn1-c1cccc(OCC(F)(F)F)c1)C(=O)N1CCN(CC1)c1ccc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
