| Reaction Details |
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 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
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| Ligand | BDBM50262777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_490133 (CHEMBL994438) |
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| EC50 | 5371±n/a nM |
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| Citation |  Zhu, C; Hansen, AR; Bateman, T; Chen, Z; Holt, TG; Hubert, JA; Karanam, BV; Lee, SJ; Pan, J; Qian, S; Reddy, VB; Reitman, ML; Strack, AM; Tong, V; Weingarth, DT; Wolff, MS; MacNeil, DJ; Weber, AE; Duffy, JL; Edmondson, SD Discovery of imidazole carboxamides as potent and selective CCK1R agonists. Bioorg Med Chem Lett18:4393-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholecystokinin receptor type A |
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| Name: | Cholecystokinin receptor type A |
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| Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 47859.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-1 receptors in HEK 293 cells. |
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| Residue: | 428 |
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| Sequence: | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
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| BDBM50262777 |
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| n/a |
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| Name | BDBM50262777 |
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| Synonyms: | (1-(3-methoxyphenyl)-2-p-tolyl-1H-imidazol-4-yl)(4-(naphthalen-1-yl)piperazin-1-yl)methanone | CHEMBL477784 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30N4O2 |
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| Mol. Mass. | 502.6062 |
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| SMILES | COc1cccc(c1)-n1cc(nc1-c1ccc(C)cc1)C(=O)N1CCN(CC1)c1cccc2ccccc12 |
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| Structure | 
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