Reaction Details |
| Report a problem with these data |
Target | Cyclin-dependent kinase 2 |
---|
Ligand | BDBM50263146 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_490603 (CHEMBL984724) |
---|
IC50 | 8±n/a nM |
---|
Citation | Finlay, MR; Acton, DG; Andrews, DM; Barker, AJ; Dennis, M; Fisher, E; Graham, MA; Green, CP; Heaton, DW; Karoutchi, G; Loddick, SA; Morgentin, R; Roberts, A; Tucker, JA; Weir, HM Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode. Bioorg Med Chem Lett18:4442-6 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cyclin-dependent kinase 2 |
---|
Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
BDBM50263146 |
---|
n/a |
---|
Name | BDBM50263146 |
Synonyms: | 5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine | CHEMBL515001 |
Type | Small organic molecule |
Emp. Form. | C21H25FN6O |
Mol. Mass. | 396.4612 |
SMILES | CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)N2CCOCC2)ncc1F |
Structure |
|