Reaction Details |
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Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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Ligand | BDBM50190543 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_564958 (CHEMBL957493) |
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Ki | 46000±n/a nM |
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Citation | McCarthy, O; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Perez, LM; Johansson, NG; Pacanowska, DG; Gilbert, IH Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. Eur J Med Chem44:678-88 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
Synonyms: | DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase |
Type: | Enzyme |
Mol. Mass.: | 26574.03 |
Organism: | Homo sapiens (Human) |
Description: | P33316 |
Residue: | 252 |
Sequence: | MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
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BDBM50190543 |
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n/a |
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Name | BDBM50190543 |
Synonyms: | 1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL377582 |
Type | Small organic molecule |
Emp. Form. | C28H27N3O4 |
Mol. Mass. | 469.5317 |
SMILES | O[C@H]1C[C@@H](O[C@@H]1CNC(c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O |r| |
Structure |
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