Reaction Details |
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Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Ligand | BDBM50266819 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_564957 (CHEMBL957492) |
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Ki | 8500±n/a nM |
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Citation | McCarthy, O; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Perez, LM; Johansson, NG; Pacanowska, DG; Gilbert, IH Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. Eur J Med Chem44:678-88 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
Synonyms: | dUTP pyrophosphatase |
Type: | Protein |
Mol. Mass.: | 19574.43 |
Organism: | Plasmodium falciparum |
Description: | Q8II92 |
Residue: | 173 |
Sequence: | MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
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BDBM50266819 |
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n/a |
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Name | BDBM50266819 |
Synonyms: | 1-(6-(tert-butyldiphenylsilylamino)hexyl)pyrimidine-2,4(1H,3H)-dione | CHEMBL515610 |
Type | Small organic molecule |
Emp. Form. | C26H35N3O2Si |
Mol. Mass. | 449.6605 |
SMILES | CC(C)(C)[Si](NCCCCCCn1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 |
Structure |
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