Reaction Details |
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Target | Liver carboxylesterase 1 |
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Ligand | BDBM50204483 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_557652 (CHEMBL961602) |
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IC50 | 200±n/a nM |
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Citation | DeMartino, JK; Garfunkle, J; Hochstatter, DG; Cravatt, BF; Boger, DL Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett18:5842-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Liver carboxylesterase 1 |
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Name: | Liver carboxylesterase 1 |
Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
Type: | Protein |
Mol. Mass.: | 62520.83 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 567 |
Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
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BDBM50204483 |
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n/a |
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Name | BDBM50204483 |
Synonyms: | 7-phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-1-one | CHEMBL373606 |
Type | Small organic molecule |
Emp. Form. | C17H18F3NO2 |
Mol. Mass. | 325.3255 |
SMILES | FC(F)(F)c1cnc(o1)C(=O)CCCCCCc1ccccc1 |
Structure |
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