Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50261820 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_514670 (CHEMBL976442) |
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IC50 | 131±n/a nM |
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Citation | Kozikowski, AP; Tapadar, S; Luchini, DN; Kim, KH; Billadeau, DD Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem51:4370-3 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50261820 |
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n/a |
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Name | BDBM50261820 |
Synonyms: | 5-(4-acetamidophenyl)-N-(7-(hydroxyamino)-7-oxoheptyl)isoxazole-3-carboxamide | CHEMBL468842 |
Type | Small organic molecule |
Emp. Form. | C19H24N4O5 |
Mol. Mass. | 388.4177 |
SMILES | CC(=O)Nc1ccc(cc1)-c1cc(no1)C(=O)NCCCCCCC(=O)NO |
Structure |
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