| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM50272366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_510155 (CHEMBL1002228) |
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| IC50 | 10±n/a nM |
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| Citation |  Heim, R; Lucas, S; Grombein, CM; Ries, C; Schewe, KE; Negri, M; Müller-Vieira, U; Birk, B; Hartmann, RW Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. J Med Chem51:5064-74 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM50272366 |
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| n/a |
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| Name | BDBM50272366 |
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| Synonyms: | 3-(1-Methoxyethyl)-5-(6-methoxynaphthalen-2-yl)pyridine | CHEMBL500392 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19NO2 |
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| Mol. Mass. | 293.3597 |
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| SMILES | COC(C)c1cncc(c1)-c1ccc2cc(OC)ccc2c1 |
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| Structure | 
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