| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50244640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_512176 (CHEMBL968035) |
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| EC50 | 160±n/a nM |
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| Citation |  Semple, G; Fioravanti, B; Pereira, G; Calderon, I; Uy, J; Choi, K; Xiong, Y; Ren, A; Morgan, M; Dave, V; Thomsen, W; Unett, DJ; Xing, C; Bossie, S; Carroll, C; Chu, ZL; Grottick, AJ; Hauser, EK; Leonard, J; Jones, RM Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem51:5172-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 36901.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TDV5 |
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| Residue: | 335 |
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| Sequence: | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
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| BDBM50244640 |
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| n/a |
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| Name | BDBM50244640 |
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| Synonyms: | 6-[4-(3-Cyclopropylmethyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl}-(4-methanesulfonyl-phenyl)-amine | CHEMBL508869 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N7O5S |
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| Mol. Mass. | 499.543 |
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| SMILES | CS(=O)(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc(CC4CC4)[n-][o+]3)c2[N+]([O-])=O)cc1 |
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| Structure | 
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