| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C alpha type |
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| Ligand | BDBM50244867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_512395 (CHEMBL979906) |
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| Ki | 72.4±n/a nM |
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| Citation |  Duan, D; Sigano, DM; Kelley, JA; Lai, CC; Lewin, NE; Kedei, N; Peach, ML; Lee, J; Abeyweera, TP; Rotenberg, SA; Kim, H; Kim, YH; El Kazzouli, S; Chung, JU; Young, HA; Young, MR; Baker, A; Colburn, NH; Haimovitz-Friedman, A; Truman, JP; Parrish, DA; Deschamps, JR; Perry, NA; Surawski, RJ; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem51:5198-220 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C alpha type |
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| Name: | Protein kinase C alpha type |
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| Synonyms: | KPCA_MOUSE | Pkca | Prkca | Protein kinase C | Protein kinase C alpha | Protein kinase C alpha type |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 76858.67 |
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| Organism: | MOUSE |
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| Description: | Protein kinase C 0 MOUSE::P20444 |
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| Residue: | 672 |
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| Sequence: | MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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| BDBM50244867 |
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| n/a |
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| Name | BDBM50244867 |
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| Synonyms: | CHEMBL472171 | rac-(E)-{2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylene]-5-oxo-2-2,3-dihydrofuryl}methyl 4-(dimethylamino)benzoate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N2O7 |
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| Mol. Mass. | 426.4193 |
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| SMILES | CN(C)c1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2cccc(c2)[N+]([O-])=O)C(=O)O1 |
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| Structure | 
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