| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50244510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_513250 (CHEMBL980886) |
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| IC50 | 44±n/a nM |
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| Citation |  Teno, N; Masuya, K; Ehara, T; Kosaka, T; Miyake, T; Irie, O; Hitomi, Y; Matsuura, N; Umemura, I; Iwasaki, G; Fukaya, H; Toriyama, K; Uchiyama, N; Nonomura, K; Sugiyama, I; Kometani, M Effect of cathepsin K inhibitors on bone resorption. J Med Chem51:5459-62 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_RAT | Ctsk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36798.82 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_633322 |
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| Residue: | 329 |
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| Sequence: | MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVH
NLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSID
YRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGG
YMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVA
RVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGE
SWGNKGYVLLARNKNNACGITNLASFPKM
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| BDBM50244510 |
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| n/a |
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| Name | BDBM50244510 |
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| Synonyms: | 7-(2,2-dimethylpropyl)-6-[(5-methoxy-2-oxospiro[indole-3,4'-piperidin]-1(2H)-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL452826 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O2 |
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| Mol. Mass. | 458.5554 |
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| SMILES | COc1ccc2N(Cc3cc4cnc(nc4n3CC(C)(C)C)C#N)C(=O)C3(CCNCC3)c2c1 |
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| Structure | 
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