| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50264707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535243 (CHEMBL981702) |
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| EC50 | 1300±n/a nM |
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| Citation |  Shen, HC; Taggart, AK; Wilsie, LC; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. Bioorg Med Chem Lett18:4948-51 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50264707 |
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| n/a |
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| Name | BDBM50264707 |
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| Synonyms: | 3-(4-isopropylphenyl)-N-(2-(4-methoxyphenoxy)ethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide | CHEMBL490221 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N4O3 |
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| Mol. Mass. | 444.5255 |
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| SMILES | COc1ccc(OCCNC(=O)c2cnc3c(cnn3c2C)-c2ccc(cc2)C(C)C)cc1 |
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| Structure | 
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