Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50264069 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_535494 (CHEMBL986121) |
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IC50 | 45±n/a nM |
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Citation | Jitsuoka, M; Tsukahara, D; Ito, S; Tanaka, T; Takenaga, N; Tokita, S; Sato, N Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett18:5101-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50264069 |
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n/a |
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Name | BDBM50264069 |
Synonyms: | CHEMBL491806 | N,2-dimethyl-3-oxo-N-[2-(piperidin-1-yl)ethyl]-2,3-dihydrospiro[isoindole-1,4'-piperidine]-1'-carboxamide |
Type | Small organic molecule |
Emp. Form. | C22H32N4O2 |
Mol. Mass. | 384.5151 |
SMILES | CN(CCN1CCCCC1)C(=O)N1CCC2(CC1)N(C)C(=O)c1ccccc21 |
Structure |
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