| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombopoietin receptor |
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| Ligand | BDBM50248106 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_497069 (CHEMBL997705) |
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| EC50 | 38±n/a nM |
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| Citation |  Marsilje, TH; Alper, PB; Lu, W; Mutnick, D; Michellys, PY; He, Y; Karanewsky, DS; Chow, D; Gerken, A; Lao, J; Kim, MJ; Seidel, HM; Tian, SS Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold. Bioorg Med Chem Lett18:5259-62 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombopoietin receptor |
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| Name: | Thrombopoietin receptor |
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| Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71243.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_535587 |
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| Residue: | 635 |
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| Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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| BDBM50248106 |
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| n/a |
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| Name | BDBM50248106 |
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| Synonyms: | CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N4O4 |
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| Mol. Mass. | 442.4666 |
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| SMILES | Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O |w:16.18| |
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| Structure | 
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