| Reaction Details |
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 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
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| Ligand | BDBM50264635 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539215 (CHEMBL1024719) |
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| IC50 | 270±n/a nM |
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| Citation |  Lu, YJ; Ou, TM; Tan, JH; Hou, JQ; Shao, WY; Peng, D; Sun, N; Wang, XD; Wu, WB; Bu, XZ; Huang, ZS; Ma, DL; Wong, KY; Gu, LQ 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation. J Med Chem51:6381-92 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Telomerase reverse transcriptase |
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| Name: | Telomerase reverse transcriptase |
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| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127099.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1447029 |
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| Residue: | 1132 |
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| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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| BDBM50264635 |
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| n/a |
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| Name | BDBM50264635 |
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| Synonyms: | CHEMBL490013 | N-(7,9-Difluoro-5-N-methyl-10H-indolo[3,2-b]quinolin-5-ium)-N,N-diethyl-propane-1,3-diamine Iodide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27F2N4 |
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| Mol. Mass. | 397.4835 |
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| SMILES | CCN(CC)CCCNc1c2[nH+]c3c(F)cc(F)cc3c2n(C)c2ccccc12 |
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| Structure | 
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