| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50249416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_492922 (CHEMBL945310) |
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| Ki | >5000±n/a nM |
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| Citation |  Farmer, LJ; Bemis, G; Britt, SD; Cochran, J; Connors, M; Harrington, EM; Hoock, T; Markland, W; Nanthakumar, S; Taslimi, P; Ter Haar, E; Wang, J; Zhaveri, D; Salituro, FG Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorg Med Chem Lett18:6231-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50249416 |
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| n/a |
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| Name | BDBM50249416 |
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| Synonyms: | CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phenyl)-4-(thiazol-2-yl)pyrimidin-2-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11F3N4S |
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| Mol. Mass. | 336.335 |
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| SMILES | Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F |
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| Structure | 
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