| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50245990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_558110 (CHEMBL959039) |
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| EC50 | 570±n/a nM |
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| Citation |  Martres, P; Faucher, N; Laroze, A; Pineau, O; Fouchet, MH; Potvain, F; Grillot, D; Beneton, V The discovery of equipotent PPARalpha/gamma dual activators. Bioorg Med Chem Lett18:6251-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50245990 |
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| n/a |
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| Name | BDBM50245990 |
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| Synonyms: | 2-(4-((5-(4-tert-butylphenyl)-1-(2-morpholinoethyl)-1H-pyrazole-3-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | CHEMBL457062 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42N4O5 |
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| Mol. Mass. | 562.6997 |
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| SMILES | Cc1cc(CNC(=O)c2cc(-c3ccc(cc3)C(C)(C)C)n(CCN3CCOCC3)n2)ccc1OC(C)(C)C(O)=O |
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| Structure | 
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