Reaction Details |
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Target | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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Ligand | BDBM50246538 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_558191 (CHEMBL962325) |
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IC50 | 1978±n/a nM |
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Citation | Bunnage, ME; Mathias, JP; Wood, A; Miller, D; Street, SD Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule. Bioorg Med Chem Lett18:6033-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
Synonyms: | PDE6A | PDE6A_CANLF | PDEA |
Type: | PROTEIN |
Mol. Mass.: | 99670.72 |
Organism: | Canis familiaris |
Description: | ChEMBL_558191 |
Residue: | 861 |
Sequence: | MGEVTAEQVEKFLDSNIIFAKQYYNLRYRAKVISDMLGAKEAAVDFSNYHSLSSVEESEI
IFDLLRDFQENLQAERCIFNVMKKLCFLLQADRMSLFMYRVRNGIAELATRLFNVHKDAV
LEECLVAPDSEIVFPLDMGVVGHVAHSKKIANVVNTEEDEHFCDFVDTLTEYQTKNILAS
PIMNGKDVVAVIMAVNKVDEPHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLAQFLGWSVLNPDTYESMNRLENRKDIFQDMVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQGELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDTKMKALEEEKQKQQTAKQGAAGD
QPGGNPSPAGGAPASKSCCIQ
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BDBM50246538 |
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n/a |
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Name | BDBM50246538 |
Synonyms: | (R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-(1-methoxypropan-2-yloxy)pyridin-3-yl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL460293 | UK-371800 |
Type | Small organic molecule |
Emp. Form. | C23H33N7O5S |
Mol. Mass. | 519.617 |
SMILES | CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)COC)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r| |
Structure |
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