Reaction Details |
| Report a problem with these data |
Target | Perforin-1 |
---|
Ligand | BDBM50274963 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_495622 (CHEMBL1000314) |
---|
IC50 | 7200±n/a nM |
---|
Citation | Lena, G; Trapani, JA; Sutton, VR; Ciccone, A; Browne, KA; Smyth, MJ; Denny, WA; Spicer, JA Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem51:7614-24 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Perforin-1 |
---|
Name: | Perforin-1 |
Synonyms: | PERF_HUMAN | PFP | PRF1 |
Type: | PROTEIN |
Mol. Mass.: | 61392.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1285138 |
Residue: | 555 |
Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
|
|
|
BDBM50274963 |
---|
n/a |
---|
Name | BDBM50274963 |
Synonyms: | (Z)-1-((6-Methoxybenzofuran-2-yl)methylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one | CHEMBL457903 |
Type | Small organic molecule |
Emp. Form. | C18H13NO4S |
Mol. Mass. | 339.365 |
SMILES | COc1ccc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc2c1 |
Structure |
|