| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Perforin-1 |
|---|
| Ligand | BDBM50274964 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_495622 (CHEMBL1000314) |
|---|
| IC50 | 3000±n/a nM |
|---|
| Citation |  Lena, G; Trapani, JA; Sutton, VR; Ciccone, A; Browne, KA; Smyth, MJ; Denny, WA; Spicer, JA Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem51:7614-24 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Perforin-1 |
|---|
| Name: | Perforin-1 |
|---|
| Synonyms: | PERF_HUMAN | PFP | PRF1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61392.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1285138 |
|---|
| Residue: | 555 |
|---|
| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
|
|
|
|---|
| BDBM50274964 |
|---|
| n/a |
|---|
| Name | BDBM50274964 |
|---|
| Synonyms: | (Z)-1-((7-Methoxybenzofuran-2-yl)methylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one | CHEMBL515997 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13NO4S |
|---|
| Mol. Mass. | 339.365 |
|---|
| SMILES | COc1cccc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc12 |
|---|
| Structure | 
|
|---|
Search and Browse
