| Reaction Details |
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 | Report a problem with these data |
| Target | Perforin-1 |
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| Ligand | BDBM50275059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_495622 (CHEMBL1000314) |
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| IC50 | 970±n/a nM |
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| Citation |  Lena, G; Trapani, JA; Sutton, VR; Ciccone, A; Browne, KA; Smyth, MJ; Denny, WA; Spicer, JA Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem51:7614-24 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Perforin-1 |
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| Name: | Perforin-1 |
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| Synonyms: | PERF_HUMAN | PFP | PRF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61392.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1285138 |
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| Residue: | 555 |
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| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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| BDBM50275059 |
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| n/a |
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| Name | BDBM50275059 |
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| Synonyms: | (Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one | CHEMBL463187 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11NO2S2 |
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| Mol. Mass. | 325.405 |
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| SMILES | Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12 |
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| Structure | 
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