| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine--tRNA ligase |
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| Ligand | BDBM50126419 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_538127 (CHEMBL1025770) |
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| IC50 | 34±n/a nM |
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| Citation |  Bamborough, P; Drewry, D; Harper, G; Smith, GK; Schneider, K Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem51:7898-914 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine--tRNA ligase |
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| Name: | Lysine--tRNA ligase |
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| Synonyms: | KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68044.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_960665 |
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| Residue: | 597 |
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| Sequence: | MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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| BDBM50126419 |
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| n/a |
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| Name | BDBM50126419 |
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| Synonyms: | CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-yl]-butane-1,4-diamine | N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5-yl)butane-1,4-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N5 |
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| Mol. Mass. | 335.446 |
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| SMILES | CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCCN)n1 |
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| Structure | 
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