Reaction Details |
| Report a problem with these data |
Target | Neuropeptide Y receptor type 1 |
---|
Ligand | BDBM50060728 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_562264 (CHEMBL1011807) |
---|
Ki | 1.5±n/a nM |
---|
Citation | Keller, M; Pop, N; Hutzler, C; Beck-Sickinger, AG; Bernhardt, G; Buschauer, A Guanidine-acylguanidine bioisosteric approach in the design of radioligands: synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. J Med Chem51:8168-72 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neuropeptide Y receptor type 1 |
---|
Name: | Neuropeptide Y receptor type 1 |
Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44399.07 |
Organism: | Homo sapiens (Human) |
Description: | NPY-Y1 NPY1R HUMAN::P25929 |
Residue: | 384 |
Sequence: | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
|
|
|
BDBM50060728 |
---|
n/a |
---|
Name | BDBM50060728 |
Synonyms: | (R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide | (R)-2-Diphenylacetylamino-5-guanidino-pentanoic acid 4-hydroxy-benzylamide | (R)-5-(diaminomethyleneamino)-2-(2,2-diphenylacetamido)-N-(4-hydroxybenzyl)pentanamide | CHEMBL332347 |
Type | Small organic molecule |
Emp. Form. | C27H31N5O3 |
Mol. Mass. | 473.5667 |
SMILES | [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6](-c1ccccc1)-c1ccccc1)-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])cc1 |r| |
Structure |
|