| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Ligand | BDBM50256181 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_518972 (CHEMBL941560) |
|---|
| Ki | 2700±n/a nM |
|---|
| Citation |  Pallavicini, M; Bolchi, C; Binda, M; Cilia, A; Clementi, F; Ferrara, R; Fumagalli, L; Gotti, C; Moretti, M; Pedretti, A; Vistoli, G; Valoti, E 5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity. Bioorg Med Chem Lett19:854-9 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70196.44 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P09483 |
|---|
| Residue: | 630 |
|---|
| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAAC
|
|
|
|---|
| BDBM50256181 |
|---|
| n/a |
|---|
| Name | BDBM50256181 |
|---|
| Synonyms: | (5S,2'S)-5-(1-methyl-2-pyrrolidinyl)oxazolidinone | CHEMBL500313 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H14N2O2 |
|---|
| Mol. Mass. | 170.209 |
|---|
| SMILES | CN1CCC[C@H]1[C@@H]1CNC(=O)O1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
