| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
|---|
| Ligand | BDBM50255647 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_515362 (CHEMBL1025517) |
|---|
| IC50 | 24±n/a nM |
|---|
| Citation |  Scott, DA; Bell, KJ; Campbell, CT; Cook, DJ; Dakin, LA; Del Valle, DJ; Drew, L; Gero, TW; Hattersley, MM; Omer, CA; Tyurin, B; Zheng, X 3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile. Bioorg Med Chem Lett19:701-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage colony-stimulating factor 1 receptor |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor |
|---|
| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 107979.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07333 |
|---|
| Residue: | 972 |
|---|
| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
|
|
|
|---|
| BDBM50255647 |
|---|
| n/a |
|---|
| Name | BDBM50255647 |
|---|
| Synonyms: | 4-(3,4-dichlorophenylamino)-6-methoxy-7-(4-methylpiperazin-1-yl)quinoline-3-carboxamide | CHEMBL519924 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23Cl2N5O2 |
|---|
| Mol. Mass. | 460.356 |
|---|
| SMILES | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)c(cnc2cc1N1CCN(C)CC1)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
