| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
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| Ligand | BDBM50255811 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_515362 (CHEMBL1025517) |
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| IC50 | 6±n/a nM |
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| Citation |  Scott, DA; Bell, KJ; Campbell, CT; Cook, DJ; Dakin, LA; Del Valle, DJ; Drew, L; Gero, TW; Hattersley, MM; Omer, CA; Tyurin, B; Zheng, X 3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile. Bioorg Med Chem Lett19:701-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage colony-stimulating factor 1 receptor |
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| Name: | Macrophage colony-stimulating factor 1 receptor |
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| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
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| Type: | Protein |
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| Mol. Mass.: | 107979.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07333 |
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| Residue: | 972 |
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| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
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| BDBM50255811 |
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| n/a |
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| Name | BDBM50255811 |
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| Synonyms: | 4-(2,4-difluorophenylamino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide | CHEMBL481806 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25F2N5O2 |
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| Mol. Mass. | 441.4737 |
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| SMILES | CCOc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1N1CCN(C)CC1 |
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| Structure | 
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