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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Transient receptor potential cation channel subfamily V member 1 | ||
| Ligand | BDBM50255426 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_515379 (CHEMBL1025534) | ||
| IC50 | 528±n/a nM | ||
| Citation |  Xiao, D; Palani, A; Aslanian, R; McKittrick, BA; McPhail, AT; Correll, CC; Phelps, PT; Anthes, JC; Rindgen, D Spiro-piperidine azetidinones as potent TRPV1 antagonists. Bioorg Med Chem Lett19:783-7 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Transient receptor potential cation channel subfamily V member 1 | |||
| Name: | Transient receptor potential cation channel subfamily V member 1 | ||
| Synonyms: | Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | TRPV1 | TRPV1_HUMAN | Transient receptor potential cation channel subfamily V member 1 | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Transient receptor potential cation channel subfamily V member 1 (VR1/TRPV1) | Transient receptor potential cation channel subfamily V member 1(TRPV1) | VR1 | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 | Vanilloid receptor 1 (TrpV1/Vr1) | Vanilloid receptor 1 (VRI/TRPV1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 94960.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8NER1 | ||
| Residue: | 839 | ||
| Sequence: |
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| BDBM50255426 | |||
| n/a | |||
| Name | BDBM50255426 | ||
| Synonyms: | (S)-N-((1s,4R)-4-tert-butylcyclohexyl)-1-oxo-2,3-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide | CHEMBL480629 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H39N3O2 | ||
| Mol. Mass. | 473.6496 | ||
| SMILES | CC(C)(C)[C@@H]1CC[C@@H](CC1)NC(=O)N1CCC2(CC1)[C@@H](N(C2=O)c1ccccc1)c1ccccc1 |r,wU:19.32,wD:7.10,4.3,(9.96,-26.87,;8.63,-26.11,;7.86,-27.44,;9.41,-24.78,;7.3,-25.34,;5.96,-26.11,;4.63,-25.33,;4.64,-23.8,;5.96,-23.03,;7.29,-23.79,;3.3,-23.03,;1.97,-23.79,;1.97,-25.33,;.64,-23.02,;-.69,-23.78,;-2.02,-23.02,;-2.03,-21.48,;-.69,-20.7,;.64,-21.48,;-2.8,-20.14,;-4.14,-20.92,;-3.36,-22.26,;-3.76,-23.75,;-5.63,-20.53,;-6.03,-19.04,;-7.51,-18.65,;-8.6,-19.74,;-8.19,-21.23,;-6.7,-21.62,;-2.41,-18.66,;-.92,-18.26,;-.53,-16.77,;-1.62,-15.68,;-3.11,-16.09,;-3.5,-17.58,)| | ||
| Structure | 
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