| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase ERG7 |
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| Ligand | BDBM50255476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_515548 (CHEMBL1036569) |
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| IC50 | 300±n/a nM |
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| Citation |  Balliano, G; Dehmlow, H; Oliaro-Bosso, S; Scaldaferri, M; Taramino, S; Viola, F; Caron, G; Aebi, J; Ackermann, J Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents. Bioorg Med Chem Lett19:718-23 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase ERG7 |
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| Name: | Lanosterol synthase ERG7 |
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| Synonyms: | ERG7 | ERG7_YEAST | Lanosterol synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83460.43 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_956105 |
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| Residue: | 731 |
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| Sequence: | MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQP
HPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEI
PEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARS
TLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYI
PVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANS
LVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEA
FQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKF
LCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHM
ISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVEC
TDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALE
ALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALI
ALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALG
MYSRAYETHTL
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| BDBM50255476 |
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| n/a |
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| Name | BDBM50255476 |
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| Synonyms: | 2-((3-(3-(4-bromophenyl)benzo[d]isothiazol-6-yl)prop-2-ynyl)(ethyl)amino)ethanol | CHEMBL481622 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19BrN2OS |
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| Mol. Mass. | 415.347 |
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| SMILES | CCN(CCO)CC#Cc1ccc2c(nsc2c1)-c1ccc(Br)cc1 |
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| Structure | 
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