| Reaction Details |
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 | Report a problem with these data |
| Target | Kynureninase |
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| Ligand | BDBM50265459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_560668 (CHEMBL1009940) |
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| Ki | 60000±n/a nM |
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| Citation |  Lima, S; Kumar, S; Gawandi, V; Momany, C; Phillips, RS Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. J Med Chem52:389-96 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynureninase |
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| Name: | Kynureninase |
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| Synonyms: | KYNU | KYNU_HUMAN | L-kynurenine hydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52356.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_91729 |
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| Residue: | 465 |
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| Sequence: | MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM
KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG
LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG
QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK
SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
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| BDBM50265459 |
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| n/a |
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| Name | BDBM50265459 |
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| Synonyms: | 3-Hydroxyhippuric acid | CHEMBL447627 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H9NO4 |
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| Mol. Mass. | 195.1721 |
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| SMILES | OC(=O)CNC(=O)c1cccc(O)c1 |
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| Structure | 
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