| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kynureninase |
|---|
| Ligand | BDBM50109155 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_560668 (CHEMBL1009940) |
|---|
| Ki | 100±n/a nM |
|---|
| Citation |  Lima, S; Kumar, S; Gawandi, V; Momany, C; Phillips, RS Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. J Med Chem52:389-96 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kynureninase |
|---|
| Name: | Kynureninase |
|---|
| Synonyms: | KYNU | KYNU_HUMAN | L-kynurenine hydrolase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52356.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_91729 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM
KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG
LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG
QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK
SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
|
|
|
|---|
| BDBM50109155 |
|---|
| n/a |
|---|
| Name | BDBM50109155 |
|---|
| Synonyms: | 2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric acid | 2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid | CHEMBL120534 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H13NO4 |
|---|
| Mol. Mass. | 211.2145 |
|---|
| SMILES | NC(CC(O)c1cccc(O)c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
