Ki Summary

Reaction Details

Report a problem with these data

Target

Serine/threonine-protein kinase Chk1

Ligand

BDBM50277024

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_540791 (CHEMBL1033194)

IC50

24000±n/a nM

Citation

Converso, A; Hartingh, T; Garbaccio, RM; Tasber, E; Rickert, K; Fraley, ME; Yan, Y; Kreatsoulas, C; Stirdivant, S; Drakas, B; Walsh, ES; Hamilton, K; Buser, CA; Mao, X; Abrams, MT; Beck, SC; Tao, W; Lobell, R; Sepp-Lorenzino, L; Zugay-Murphy, J; Sardana, V; Munshi, SK; Jezequel-Sur, SM; Zuck, PD; Hartman, GD Development of thioquinazolinones, allosteric Chk1 kinase inhibitors. Bioorg Med Chem Lett19:1240-4 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase Chk1

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

BDBM50277024

n/a

Name

BDBM50277024

Synonyms:

1-(2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)hexanoyl)piperidine-4-carboxamide | CHEMBL460003

Type

Small organic molecule

Emp. Form.

C26H30N4O3S

Mol. Mass.

478.606

SMILES

CCCCC(Sc1nc2ccccc2c(=O)n1-c1ccccc1)C(=O)N1CCC(CC1)C(N)=O

Structure