| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM13017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_541073 (CHEMBL1024773) |
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| Ki | 120±n/a nM |
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| Citation |  Wu, Q; Caine, JM; Thomson, SA; Slavica, M; Grunewald, GL; McLeish, MJ Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline. Bioorg Med Chem Lett19:1071-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30852.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 282 |
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| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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| BDBM13017 |
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| n/a |
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| Name | BDBM13017 |
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| Synonyms: | 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHEMBL26717 | SKF 29661 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H12N2O2S |
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| Mol. Mass. | 212.269 |
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| SMILES | NS(=O)(=O)c1ccc2CCNCc2c1 |
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| Structure | 
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