| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 2 |
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| Ligand | BDBM50248546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_566228 (CHEMBL963309) |
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| Ki | 10000±n/a nM |
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| Citation |  Biju, P; Taveras, AG; Yu, Y; Zheng, J; Hipkin, RW; Fossetta, J; Fan, X; Fine, J; Lundell, D 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists. Bioorg Med Chem Lett19:1434-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 2 |
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| Name: | C-X-C chemokine receptor type 2 |
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| Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B |
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| Type: | Protein |
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| Mol. Mass.: | 40767.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25025 |
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| Residue: | 360 |
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| Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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| BDBM50248546 |
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| n/a |
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| Name | BDBM50248546 |
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| Synonyms: | (S)-3-(4-(3,3-dimethylbutan-2-ylamino)-1,2,5-thiadiazol-3-ylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL464302 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25N5O2S |
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| Mol. Mass. | 363.478 |
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| SMILES | C[C@H](Nc1nsnc1Nc1cccc(C(=O)N(C)C)c1O)C(C)(C)C |r| |
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| Structure | 
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