Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50257684 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_565967 (CHEMBL960863) |
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EC50 | 14±n/a nM |
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Citation | Owen, DR; Rodriguez-Lens, M; Corless, MD; Gaulier, SM; Horne, VA; Kinloch, RA; Maw, GN; Pearce, DW; Rees, H; Ringer, TJ; Ryckmans, T; Stammen, BL 2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology. Bioorg Med Chem Lett19:1702-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50257684 |
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n/a |
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Name | BDBM50257684 |
Synonyms: | CHEMBL495346 | N-(1-(4-aminopyridin-2-yl)-4-phenylpiperidin-4-yl)-2,4-dimethoxybenzamide |
Type | Small organic molecule |
Emp. Form. | C25H28N4O3 |
Mol. Mass. | 432.5148 |
SMILES | COc1ccc(C(=O)NC2(CCN(CC2)c2cc(N)ccn2)c2ccccc2)c(OC)c1 |
Structure |
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