Reaction Details |
| Report a problem with these data |
Target | Delta-type opioid receptor |
---|
Ligand | BDBM50257834 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_565967 (CHEMBL960863) |
---|
EC50 | 41±n/a nM |
---|
Citation | Owen, DR; Rodriguez-Lens, M; Corless, MD; Gaulier, SM; Horne, VA; Kinloch, RA; Maw, GN; Pearce, DW; Rees, H; Ringer, TJ; Ryckmans, T; Stammen, BL 2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology. Bioorg Med Chem Lett19:1702-6 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Delta-type opioid receptor |
---|
Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
|
|
|
BDBM50257834 |
---|
n/a |
---|
Name | BDBM50257834 |
Synonyms: | 3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-(cyclopropylmethyl)-1H-imidazo[4,5-b]pyridin-2(3H)-one | CHEMBL523504 |
Type | Small organic molecule |
Emp. Form. | C20H24N6O |
Mol. Mass. | 364.4442 |
SMILES | Nc1ccnc(c1)N1CCC(CC1)n1c2ncccc2n(CC2CC2)c1=O |
Structure |
|