Reaction Details |
| Report a problem with these data |
Target | Gonadotropin-releasing hormone receptor |
---|
Ligand | BDBM50256883 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_562460 (CHEMBL1010963) |
---|
IC50 | 21±n/a nM |
---|
Citation | Pelletier, JC; Chengalvala, MV; Cottom, JE; Feingold, IB; Green, DM; Hauze, DB; Huselton, CA; Jetter, JW; Kopf, GS; Lundquist, JT; Magolda, RL; Mann, CW; Mehlmann, JF; Rogers, JF; Shanno, LK; Adams, WR; Tio, CO; Wrobel, JE Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J Med Chem52:2148-52 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Gonadotropin-releasing hormone receptor |
---|
Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
|
|
|
BDBM50256883 |
---|
n/a |
---|
Name | BDBM50256883 |
Synonyms: | 6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)quinoline | CHEMBL474992 |
Type | Small organic molecule |
Emp. Form. | C31H33N5 |
Mol. Mass. | 475.6272 |
SMILES | CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2ccc3ncccc3c2)CC1 |
Structure |
|