Reaction Details |
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Target | Dipeptidyl peptidase 3 |
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Ligand | BDBM50249479 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_499550 (CHEMBL1010598) |
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IC50 | >30000±n/a nM |
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Citation | Ammirati, MJ; Andrews, KM; Boyer, DD; Brodeur, AM; Danley, DE; Doran, SD; Hulin, B; Liu, S; McPherson, RK; Orena, SJ; Parker, JC; Polivkova, J; Qiu, X; Soglia, CB; Treadway, JL; VanVolkenburg, MA; Wilder, DC; Piotrowski, DW (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor. Bioorg Med Chem Lett19:1991-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dipeptidyl peptidase 3 |
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Name: | Dipeptidyl peptidase 3 |
Synonyms: | DPP3 | DPP3_HUMAN | Dipeptidyl arylamidase III | Dipeptidyl peptidase 3 | Dipeptidyl peptidase III | Dipeptidyl peptidase III (DPP III) |
Type: | Enzyme |
Mol. Mass.: | 82565.94 |
Organism: | Homo sapiens (Human) |
Description: | Q9NY33 |
Residue: | 737 |
Sequence: | MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIY
ALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPK
EKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMED
AKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFR
GSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFW
IQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWP
PTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQ
REKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPE
TGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIY
VNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPD
ARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRD
TVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLAT
ADARFWKGPSEAPSGQA
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BDBM50249479 |
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n/a |
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Name | BDBM50249479 |
Synonyms: | 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine | CHEMBL515387 | PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone |
Type | Small organic molecule |
Emp. Form. | C17H24F2N6O |
Mol. Mass. | 366.4089 |
SMILES | FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ncccn1 |r| |
Structure |
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