Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50278040 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_501283 (CHEMBL971469) |
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Ki | 14±n/a nM |
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Citation | Leblanc, Y; Roy, P; Dufresne, C; Lachance, N; Wang, Z; O'Neill, G; Greig, G; Denis, D; Mathieu, MC; Slipetz, D; Sawyer, N; Tsou, N Discovery of potent and selective DP1 receptor antagonists in the azaindole series. Bioorg Med Chem Lett19:2125-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50278040 |
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n/a |
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Name | BDBM50278040 |
Synonyms: | (+/-)-2-(5-(3,4-dichlorophenylthio)-4-isopropyl-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-6-yl)acetic acid | CHEMBL521290 |
Type | Small organic molecule |
Emp. Form. | C22H22Cl2N2O2S |
Mol. Mass. | 449.393 |
SMILES | CC(C)c1ccnc2n3CCCC(CC(O)=O)c3c(Sc3ccc(Cl)c(Cl)c3)c12 |
Structure |
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