Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50267614 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_562972 (CHEMBL1015371) |
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Ki | 0.15±n/a nM |
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Citation | Lainé, DI; McCleland, B; Thomas, S; Neipp, C; Underwood, B; Dufour, J; Widdowson, KL; Palovich, MR; Blaney, FE; Foley, JJ; Webb, EF; Luttmann, MA; Burman, M; Belmonte, K; Salmon, M Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem52:2493-505 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
Type: | GPCR |
Mol. Mass.: | 51730.61 |
Organism: | Homo sapiens (Human) |
Description: | P08172 |
Residue: | 466 |
Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50267614 |
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n/a |
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Name | BDBM50267614 |
Synonyms: | 4-[Hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane Bromide | CHEMBL523299 | GSK573719 | Umeclidinium | Umeclidinium bromide | incruse | incruse ellipta |
Type | Small organic molecule |
Emp. Form. | C29H34NO2 |
Mol. Mass. | 428.5852 |
SMILES | OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2 |
Structure |
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