Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Cholesteryl ester transfer protein | ||
Ligand | BDBM50276347 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_501358 (CHEMBL1010541) | ||
IC50 | 33±n/a nM | ||
Citation | Rano, TA; Sieber-McMaster, E; Pelton, PD; Yang, M; Demarest, KT; Kuo, GH Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform. Bioorg Med Chem Lett19:2456-60 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cholesteryl ester transfer protein | |||
Name: | Cholesteryl ester transfer protein | ||
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I | ||
Type: | Enzyme | ||
Mol. Mass.: | 54751.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11597 | ||
Residue: | 493 | ||
Sequence: |
| ||
BDBM50276347 | |||
n/a | |||
Name | BDBM50276347 | ||
Synonyms: | (+/-)-1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol | 1,1,1-trifluoro-3-(2-(2-(1,1,2,2-tetrafluoroethoxy) phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol | 1,1,1-trifluoro-3-(2-(2-(1,1,2,2-tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol | 1,1,1-trifluoro-3-(2-(3-(1,1,2,2 -tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol | 1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)-5-(3-(trifluoromethoxy)phenyl)-3,4-dihydroquinolin-1(2H)-yl)propan-2-ol | CHEMBL479339 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H21F10NO3 | ||
Mol. Mass. | 597.4446 | ||
SMILES | OC(CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F | ||
Structure |