Reaction Details |
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Target | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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Ligand | BDBM27533 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_501487 (CHEMBL984126) |
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Kd | 70±n/a nM |
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Citation | Lehtiö, L; Jemth, AS; Collins, R; Loseva, O; Johansson, A; Markova, N; Hammarström, M; Flores, A; Holmberg-Schiavone, L; Weigelt, J; Helleday, T; Schüler, H; Karlberg, T Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem52:3108-11 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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Name: | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
Synonyms: | (ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3) |
Type: | PROTEIN |
Mol. Mass.: | 60071.85 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y6F1[R100H] |
Residue: | 533 |
Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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BDBM27533 |
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n/a |
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Name | BDBM27533 |
Synonyms: | 4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one | 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one | 4-[[3-(1,4-Diazepane-1-carbonyl)-4-fluorophenyl]methyl]-2Hphthalazin-1-one | 4-{[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one | CHEMBL380648 | Homopiperazine analogue, 14 | KU-0058948 |
Type | Small organic molecule |
Emp. Form. | C21H21FN4O2 |
Mol. Mass. | 380.4154 |
SMILES | Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCCNCC1 |
Structure |
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