Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50218689 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_501500 (CHEMBL984139) |
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IC50 | 79±n/a nM |
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Citation | Cirillo, PF; Hickey, ER; Moss, N; Breitfelder, S; Betageri, R; Fadra, T; Gaenzler, F; Gilmore, T; Goldberg, DR; Kamhi, V; Kirrane, T; Kroe, RR; Madwed, J; Moriak, M; Netherton, M; Pargellis, CA; Patel, UR; Qian, KC; Sharma, R; Sun, S; Swinamer, A; Torcellini, C; Takahashi, H; Tsang, M; Xiong, Z Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors. Bioorg Med Chem Lett19:2386-91 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50218689 |
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n/a |
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Name | BDBM50218689 |
Synonyms: | CHEMBL245230 | N-(5-tert-butyl-2-methoxy-3-(3-naphthalen-1-ylureido)phenyl)methanesulfonamide | N-[5-tert-butyl-2-methoxy-3-(3-naphthalen-1-yl-ureido)-phenyl]-methanesulfonamide |
Type | Small organic molecule |
Emp. Form. | C23H27N3O4S |
Mol. Mass. | 441.543 |
SMILES | COc1c(NC(=O)Nc2cccc3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C |
Structure |
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