| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
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| Ligand | BDBM50258450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_500271 (CHEMBL969606) |
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| IC50 | >10000±n/a nM |
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| Citation |  Suzuki, T; Moriya, M; Sakamoto, T; Suga, T; Kishino, H; Takahashi, H; Ishikawa, M; Nagai, K; Imai, Y; Sekino, E; Ito, M; Iwaasa, H; Ishihara, A; Tokita, S; Kanatani, A; Sato, N; Fukami, T Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett19:3072-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A adrenergic receptor |
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| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 51511.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35348 |
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| Residue: | 466 |
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| Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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| BDBM50258450 |
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| n/a |
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| Name | BDBM50258450 |
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| Synonyms: | (+/-)-2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)propyl)-N-methyl-2-(1H-pyrazol-1-yl)acetamide | 2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)propyl)-N-methyl-2-(1H-pyrazol-1-yl)acetamide | CHEMBL466425 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28F3N5O2 |
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| Mol. Mass. | 499.528 |
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| SMILES | CN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 |
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| Structure | 
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