Found 175 hits with Last Name = 'kishino' and Initial = 'h' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258478
(2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[fur...)Show SMILES FCCN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C27H29F4N5O2/c28-7-14-35(26(37)25(36-11-1-8-33-36)19-3-4-22(29)23(30)15-19)10-2-9-34-12-5-27(6-13-34)21-17-32-24(31)16-20(21)18-38-27/h1,3-4,8,11,15-17,25H,2,5-7,9-10,12-14,18H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258477
(2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-1H-s...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C27H30F3N5O2/c1-2-34(26(36)25(35-12-3-9-32-35)19-5-6-22(28)23(29)15-19)11-4-10-33-13-7-27(8-14-33)21-17-31-24(30)16-20(21)18-37-27/h3,5-6,9,12,15-17,25H,2,4,7-8,10-11,13-14,18H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333594
(4-(Naphthalen-2-ylmethoxy)-1-{4-[2-(pyrrolidin-1-y...)Show SMILES O=c1cc(OCc2ccc3ccccc3c2)ccn1-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C28H28N2O3/c31-28-20-27(33-21-22-7-8-23-5-1-2-6-24(23)19-22)13-16-30(28)25-9-11-26(12-10-25)32-18-17-29-14-3-4-15-29/h1-2,5-13,16,19-20H,3-4,14-15,17-18,21H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333604
(1-(4-{2-[Benzyl(methyl)amino]ethoxy}phenyl)-4-(ben...)Show SMILES CN(CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O)Cc1ccccc1 Show InChI InChI=1S/C28H28N2O3/c1-29(21-23-8-4-2-5-9-23)18-19-32-26-14-12-25(13-15-26)30-17-16-27(20-28(30)31)33-22-24-10-6-3-7-11-24/h2-17,20H,18-19,21-22H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258315
((+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine...)Show SMILES CN(CCCN1CCC2(CC1)OCc1ccccc21)C(=O)C(c1ccccc1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C30H32F2N2O2/c1-33(29(35)28(22-8-3-2-4-9-22)23-12-13-26(31)27(32)20-23)16-7-17-34-18-14-30(15-19-34)25-11-6-5-10-24(25)21-36-30/h2-6,8-13,20,28H,7,14-19,21H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333616
(4-[(4-Methoxybenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)...)Show SMILES COc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1 Show InChI InChI=1S/C25H28N2O4/c1-29-22-8-4-20(5-9-22)19-31-24-12-15-27(25(28)18-24)21-6-10-23(11-7-21)30-17-16-26-13-2-3-14-26/h4-12,15,18H,2-3,13-14,16-17,19H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258450
((+/-)-2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spi...)Show SMILES CN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C26H28F3N5O2/c1-32(25(35)24(34-11-2-8-31-34)18-4-5-21(27)22(28)14-18)9-3-10-33-12-6-26(7-13-33)20-16-30-23(29)15-19(20)17-36-26/h2,4-5,8,11,14-16,24H,3,6-7,9-10,12-13,17H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258450
((+/-)-2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spi...)Show SMILES CN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C26H28F3N5O2/c1-32(25(35)24(34-11-2-8-31-34)18-4-5-21(27)22(28)14-18)9-3-10-33-12-6-26(7-13-33)20-16-30-23(29)15-19(20)17-36-26/h2,4-5,8,11,14-16,24H,3,6-7,9-10,12-13,17H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50162116
(2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)e...)Show SMILES O=C(Cc1ccc(OCc2ccccc2)cc1)Nc1ccc2cnn(CCN3CCCC3)c2c1 Show InChI InChI=1S/C28H30N4O2/c33-28(18-22-8-12-26(13-9-22)34-21-23-6-2-1-3-7-23)30-25-11-10-24-20-29-32(27(24)19-25)17-16-31-14-4-5-15-31/h1-3,6-13,19-20H,4-5,14-18,21H2,(H,30,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50333615
(4-[(4-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)e...)Show SMILES Clc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1 Show InChI InChI=1S/C24H25ClN2O3/c25-20-5-3-19(4-6-20)18-30-23-11-14-27(24(28)17-23)21-7-9-22(10-8-21)29-16-15-26-12-1-2-13-26/h3-11,14,17H,1-2,12-13,15-16,18H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333615
(4-[(4-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)e...)Show SMILES Clc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1 Show InChI InChI=1S/C24H25ClN2O3/c25-20-5-3-19(4-6-20)18-30-23-11-14-27(24(28)17-23)21-7-9-22(10-8-21)29-16-15-26-12-1-2-13-26/h3-11,14,17H,1-2,12-13,15-16,18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258417
((+/-)-N-(3-(3'H-spiro[cyclohexane-1,1'-isobenzofur...)Show SMILES CN(CCCC1CCC2(CC1)OCc1ccccc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C28H31F2N3O2/c1-32(27(34)26(33-17-5-15-31-33)21-9-10-24(29)25(30)18-21)16-4-6-20-11-13-28(14-12-20)23-8-3-2-7-22(23)19-35-28/h2-3,5,7-10,15,17-18,20,26H,4,6,11-14,16,19H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333611
(4-(Benzyloxy)-1-(4-{[2-(diethylamino)ethyl](methyl...)Show SMILES CCN(CC)CCN(C)c1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O Show InChI InChI=1S/C25H31N3O2/c1-4-27(5-2)18-17-26(3)22-11-13-23(14-12-22)28-16-15-24(19-25(28)29)30-20-21-9-7-6-8-10-21/h6-16,19H,4-5,17-18,20H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258418
((+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine...)Show SMILES CN(CCCN1CCC2(CC1)OCc1ccccc21)C(=O)C(c1ccc(F)c(F)c1)n1ccnn1 Show InChI InChI=1S/C26H29F2N5O2/c1-31(25(34)24(33-16-11-29-30-33)19-7-8-22(27)23(28)17-19)12-4-13-32-14-9-26(10-15-32)21-6-3-2-5-20(21)18-35-26/h2-3,5-8,11,16-17,24H,4,9-10,12-15,18H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333618
(4-[(3-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)e...)Show SMILES Clc1cccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)c1 Show InChI InChI=1S/C24H25ClN2O3/c25-20-5-3-4-19(16-20)18-30-23-10-13-27(24(28)17-23)21-6-8-22(9-7-21)29-15-14-26-11-1-2-12-26/h3-10,13,16-17H,1-2,11-12,14-15,18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297070
(CHEMBL560474 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-2-3-16)27-21-11-9-19(13-28(14)21)26-23(29)20-10-6-17(12-25-20)15-4-7-18(24)8-5-15/h4-13,16H,2-3H2,1H3,(H,26,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258276
(1-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-y...)Show SMILES CN(CCCN1CCC2(CC1)OCc1ccccc21)C(=O)N(c1ccc(C)cc1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C30H33F2N3O2/c1-22-8-10-24(11-9-22)35(25-12-13-27(31)28(32)20-25)29(36)33(2)16-5-17-34-18-14-30(15-19-34)26-7-4-3-6-23(26)21-37-30/h3-4,6-13,20H,5,14-19,21H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258275
(1-(3,4-difluorophenyl)-3-(3-(2,3-dihydrospiro[inde...)Show SMILES CN(CCCN1CCC2(CCc3ccccc23)CC1)C(=O)N(c1ccc(C)cc1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C31H35F2N3O/c1-23-8-10-25(11-9-23)36(26-12-13-28(32)29(33)22-26)30(37)34(2)18-5-19-35-20-16-31(17-21-35)15-14-24-6-3-4-7-27(24)31/h3-4,6-13,22H,5,14-21H2,1-2H3 | Reactome pathway
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| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297062
(4-(5-chloropyridin-2-yl)-N-(2-cyclopropyl-3-methyl...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cn3)cn12)C1CC1 Show InChI InChI=1S/C23H19ClN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)20-10-8-18(24)12-25-20/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333617
(1-{4-[2-(Pyrrolidin-1-yl)ethoxy]phenyl}-4-{[4-(tri...)Show SMILES FC(F)(F)c1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1 Show InChI InChI=1S/C25H25F3N2O3/c26-25(27,28)20-5-3-19(4-6-20)18-33-23-11-14-30(24(31)17-23)21-7-9-22(10-8-21)32-16-15-29-12-1-2-13-29/h3-11,14,17H,1-2,12-13,15-16,18H2 | PDB
MMDB
Reactome pathway
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UniChem
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| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297073
(CHEMBL564106 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C22H18FN5O/c1-13-21(15-2-3-15)27-20-9-8-17(12-28(13)20)26-22(29)19-11-24-18(10-25-19)14-4-6-16(23)7-5-14/h4-12,15H,2-3H2,1H3,(H,26,29) | Reactome pathway
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258449
((+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine...)Show SMILES CN(CCCN1CCC2(CC1)OCc1ccccc21)C(=O)C(N1CCCC1=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C28H33F2N3O3/c1-31(27(35)26(33-15-4-8-25(33)34)20-9-10-23(29)24(30)18-20)13-5-14-32-16-11-28(12-17-32)22-7-3-2-6-21(22)19-36-28/h2-3,6-7,9-10,18,26H,4-5,8,11-17,19H2,1H3 | Reactome pathway
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PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30177
(2-aminobenzimidazole-based compound, 25)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cc2[nH]1 Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-17-9-8-16(10-18(17)28-22)26-21(30)20-12-24-19(11-25-20)14-4-6-15(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28) | Reactome pathway
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PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333614
(4-[(3-Fluorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)e...)Show SMILES Fc1cccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)c1 Show InChI InChI=1S/C24H25FN2O3/c25-20-5-3-4-19(16-20)18-30-23-10-13-27(24(28)17-23)21-6-8-22(9-7-21)29-15-14-26-11-1-2-12-26/h3-10,13,16-17H,1-2,11-12,14-15,18H2 | PDB
MMDB
Reactome pathway
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UniChem
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| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258419
((+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine...)Show SMILES CN(CCCN1CCC2(CC1)OCc1ccccc21)C(=O)C(c1ccc(F)c(F)c1)n1cncn1 Show InChI InChI=1S/C26H29F2N5O2/c1-31(25(34)24(33-18-29-17-30-33)19-7-8-22(27)23(28)15-19)11-4-12-32-13-9-26(10-14-32)21-6-3-2-5-20(21)16-35-26/h2-3,5-8,15,17-18,24H,4,9-14,16H2,1H3 | Reactome pathway
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| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30172
(2-aminobenzimidazole-based compound, 20)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C24H22F3N5O/c1-14(2)32(3)23-30-20-11-9-18(12-21(20)31-23)29-22(33)16-6-4-15(5-7-16)19-10-8-17(13-28-19)24(25,26)27/h4-14H,1-3H3,(H,29,33)(H,30,31) | Reactome pathway
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| PC cid
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Similars
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PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297061
(CHEMBL551934 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccccn3)cn12)C1CC1 Show InChI InChI=1S/C23H20N4O/c1-15-22(17-7-8-17)26-21-12-11-19(14-27(15)21)25-23(28)18-9-5-16(6-10-18)20-4-2-3-13-24-20/h2-6,9-14,17H,7-8H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297059
(CHEMBL561134 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C24H19F3N4O/c1-14-22(16-4-5-16)30-21-11-9-19(13-31(14)21)29-23(32)17-6-2-15(3-7-17)20-10-8-18(12-28-20)24(25,26)27/h2-3,6-13,16H,4-5H2,1H3,(H,29,32) | Reactome pathway
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| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50333604
(1-(4-{2-[Benzyl(methyl)amino]ethoxy}phenyl)-4-(ben...)Show SMILES CN(CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O)Cc1ccccc1 Show InChI InChI=1S/C28H28N2O3/c1-29(21-23-8-4-2-5-9-23)18-19-32-26-14-12-25(13-15-26)30-17-16-27(20-28(30)31)33-22-24-10-6-3-7-11-24/h2-17,20H,18-19,21-22H2,1H3 | Reactome pathway
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PC sid
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| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30164
(2-aminobenzimidazole-based compound, 12)Show SMILES CN(C1CCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C23H25F3N4O/c1-30(18-4-2-3-5-18)22-28-19-12-11-17(14-20(19)29-22)27-21(31)13-8-15-6-9-16(10-7-15)23(24,25)26/h6-7,9-12,14,18H,2-5,8,13H2,1H3,(H,27,31)(H,28,29) | Reactome pathway
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PubMed
| n/a | n/a | 4 | n/a | 22 | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297071
(CHEMBL562136 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)cc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-2-3-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-10-20(25-12-17)15-4-7-18(24)8-5-15/h4-13,16H,2-3H2,1H3,(H,26,29) | Reactome pathway
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297067
(CHEMBL565105 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(nc3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C24H19F3N4O/c1-14-22(16-4-5-16)30-21-11-9-19(13-31(14)21)29-23(32)17-6-2-15(3-7-17)18-8-10-20(28-12-18)24(25,26)27/h2-3,6-13,16H,4-5H2,1H3,(H,29,32) | Reactome pathway
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50333618
(4-[(3-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)e...)Show SMILES Clc1cccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)c1 Show InChI InChI=1S/C24H25ClN2O3/c25-20-5-3-4-19(16-20)18-30-23-10-13-27(24(28)17-23)21-6-8-22(9-7-21)29-15-14-26-11-1-2-12-26/h3-10,13,16-17H,1-2,11-12,14-15,18H2 | Reactome pathway
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| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333613
(4-[(2-Fluorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)e...)Show SMILES Fc1ccccc1COc1ccn(-c2ccc(OCCN3CCCC3)cc2)c(=O)c1 Show InChI InChI=1S/C24H25FN2O3/c25-23-6-2-1-5-19(23)18-30-22-11-14-27(24(28)17-22)20-7-9-21(10-8-20)29-16-15-26-12-3-4-13-26/h1-2,5-11,14,17H,3-4,12-13,15-16,18H2 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333603
(4-(Benzyloxy)-1-{4-[2-(diisopropylamino)ethoxy]-ph...)Show SMILES CC(C)N(CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O)C(C)C Show InChI InChI=1S/C26H32N2O3/c1-20(2)27(21(3)4)16-17-30-24-12-10-23(11-13-24)28-15-14-25(18-26(28)29)31-19-22-8-6-5-7-9-22/h5-15,18,20-21H,16-17,19H2,1-4H3 | PDB
MMDB
Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50333596
(4-(Benzyloxy)-1-{4-[2-(piperidin-1-yl)ethoxy]pheny...)Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cc1 Show InChI InChI=1S/C25H28N2O3/c28-25-19-24(30-20-21-7-3-1-4-8-21)13-16-27(25)22-9-11-23(12-10-22)29-18-17-26-14-5-2-6-15-26/h1,3-4,7-13,16,19H,2,5-6,14-15,17-18,20H2 | Reactome pathway
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| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297068
(CHEMBL551470 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(F)nc3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)18-8-10-20(24)25-12-18/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
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| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297042
(CHEMBL557731 | N-(2-methylimidazo[1,2-a]pyridin-6-...)Show SMILES Cc1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C22H16F3N3O/c1-14-12-28-13-19(10-11-20(28)26-14)27-21(29)17-4-2-15(3-5-17)16-6-8-18(9-7-16)22(23,24)25/h2-13H,1H3,(H,27,29) | Reactome pathway
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PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297052
(CHEMBL563725 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)cn12)C1CC1 Show InChI InChI=1S/C25H20F3N3O/c1-15-23(18-4-5-18)30-22-13-12-21(14-31(15)22)29-24(32)19-6-2-16(3-7-19)17-8-10-20(11-9-17)25(26,27)28/h2-3,6-14,18H,4-5H2,1H3,(H,29,32) | Reactome pathway
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| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297064
(CHEMBL563728 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(C)cn3)cn12)C1CC1 Show InChI InChI=1S/C24H22N4O/c1-15-3-11-21(25-13-15)17-4-8-19(9-5-17)24(29)26-20-10-12-22-27-23(18-6-7-18)16(2)28(22)14-20/h3-5,8-14,18H,6-7H2,1-2H3,(H,26,29) | Reactome pathway
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| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50333603
(4-(Benzyloxy)-1-{4-[2-(diisopropylamino)ethoxy]-ph...)Show SMILES CC(C)N(CCOc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O)C(C)C Show InChI InChI=1S/C26H32N2O3/c1-20(2)27(21(3)4)16-17-30-24-12-10-23(11-13-24)28-15-14-25(18-26(28)29)31-19-22-8-6-5-7-9-22/h5-15,18,20-21H,16-17,19H2,1-4H3 | Reactome pathway
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| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297063
(CHEMBL559680 | N-(2-cyclopropyl-3-methylimidazo[1,...)Show SMILES Cc1c(nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(F)cn3)cn12)C1CC1 Show InChI InChI=1S/C23H19FN4O/c1-14-22(16-4-5-16)27-21-11-9-19(13-28(14)21)26-23(29)17-6-2-15(3-7-17)20-10-8-18(24)12-25-20/h2-3,6-13,16H,4-5H2,1H3,(H,26,29) | Reactome pathway
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297041
(CHEMBL557664 | N-(2-isopropylimidazo[1,2-a]pyridin...)Show SMILES CC(C)c1cn2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C24H20F3N3O/c1-15(2)21-14-30-13-20(11-12-22(30)29-21)28-23(31)18-5-3-16(4-6-18)17-7-9-19(10-8-17)24(25,26)27/h3-15H,1-2H3,(H,28,31) | Reactome pathway
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50150715
(4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethyla...)Show SMILES CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(F)cc3)ccc2C1 Show InChI InChI=1S/C26H27FN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30) | Reactome pathway
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| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM30174
(2-aminobenzimidazole-based compound, 22)Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)cc3)cc2[nH]1 Show InChI InChI=1S/C23H22FN5O/c1-14(2)29(3)23-27-20-11-9-18(12-21(20)28-23)26-22(30)16-6-10-19(25-13-16)15-4-7-17(24)8-5-15/h4-14H,1-3H3,(H,26,30)(H,27,28) | Reactome pathway
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| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Banyu Pharmaceutical Co.
| Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w... |
Bioorg Med Chem Lett 19: 3568-72 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50297044
(CHEMBL557730 | N-(2-cyclopropylimidazo[1,2-a]pyrid...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2nc(cn2c1)C1CC1 Show InChI InChI=1S/C24H18F3N3O/c25-24(26,27)19-9-7-16(8-10-19)15-1-5-18(6-2-15)23(31)28-20-11-12-22-29-21(17-3-4-17)14-30(22)13-20/h1-2,5-14,17H,3-4H2,(H,28,31) | Reactome pathway
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| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1 receptor |
Bioorg Med Chem Lett 19: 4589-93 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.101
BindingDB Entry DOI: 10.7270/Q2SN091G |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50301081
(4-(4-fluorobenzyloxy)-1-(4-(2-(pyrrolidin-1-yl)eth...)Show SMILES Fc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1 Show InChI InChI=1S/C24H25FN2O3/c25-20-5-3-19(4-6-20)18-30-23-11-14-27(24(28)17-23)21-7-9-22(10-8-21)29-16-15-26-12-1-2-13-26/h3-11,14,17H,1-2,12-13,15-16,18H2 | Reactome pathway
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PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50333597
(4-(Benzyloxy)-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phen...)Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCC2)cc1 Show InChI InChI=1S/C24H26N2O3/c27-24-18-23(29-19-20-6-2-1-3-7-20)12-15-26(24)21-8-10-22(11-9-21)28-17-16-25-13-4-5-14-25/h1-3,6-12,15,18H,4-5,13-14,16-17,19H2 | Reactome pathway
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333596
(4-(Benzyloxy)-1-{4-[2-(piperidin-1-yl)ethoxy]pheny...)Show SMILES O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cc1 Show InChI InChI=1S/C25H28N2O3/c28-25-19-24(30-20-21-7-3-1-4-8-21)13-16-27(25)22-9-11-23(12-10-22)29-18-17-26-14-5-2-6-15-26/h1,3-4,7-13,16,19H,2,5-6,14-15,17-18,20H2 | PDB
MMDB
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50333607
(4-(Benzyloxy)-1-{4-[(1-methylpiperidin-2-yl)methox...)Show SMILES CN1CCCCC1COc1ccc(cc1)-n1ccc(OCc2ccccc2)cc1=O Show InChI InChI=1S/C25H28N2O3/c1-26-15-6-5-9-22(26)19-30-23-12-10-21(11-13-23)27-16-14-24(17-25(27)28)29-18-20-7-3-2-4-8-20/h2-4,7-8,10-14,16-17,22H,5-6,9,15,18-19H2,1H3 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [35S]N-[(4R)-10-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,40-piperidin]-6-yl]methanes... |
Bioorg Med Chem 19: 883-93 (2011)
Article DOI: 10.1016/j.bmc.2010.12.002
BindingDB Entry DOI: 10.7270/Q2GT5NFT |
More data for this
Ligand-Target Pair | |
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