Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50258683 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_500545 (CHEMBL971410) |
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IC50 | >30000±n/a nM |
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Citation | Tapadar, S; He, R; Luchini, DN; Billadeau, DD; Kozikowski, AP Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett19:3023-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50258683 |
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n/a |
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Name | BDBM50258683 |
Synonyms: | 5-(5-oxo-5-(4-phenylthiazol-2-ylamino)pentyl)isoxazole-3-carboxylic acid | CHEMBL466032 |
Type | Small organic molecule |
Emp. Form. | C18H17N3O4S |
Mol. Mass. | 371.41 |
SMILES | OC(=O)c1cc(CCCCC(=O)Nc2nc(cs2)-c2ccccc2)on1 |
Structure |
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